A round, raised skin lesion with itching is indicative of what?

The correct answer is that a round, raised skin lesion with itching is indicative of a wheal. A wheal is characterized by its raised appearance and often has a pale color in the center with a red surrounding area. It is typically associated with allergic reactions, such as hives, and is also known for causing itching or a burning sensation.

The other choices describe different types of skin lesions. A blister refers to a fluid-filled sac, usually arising from friction or irritation, rather than a raised area that is itchy without fluid. A papule is also a raised lesion, but it does not typically have the same characteristics of itching and is usually solid and less than 1 centimeter in size. A vesicle is another type of fluid-filled lesion that is smaller than a blister and can also be itchy, but it is specifically liquid-filled unlike a wheal, which is due to an accumulation of fluid in the surrounding tissues.

Thus, while each choice presents various types of skin lesions, the description of a round, raised lesion with itching aligns most accurately with a wheal.